منابع مشابه
Telomerase Activity in Articular Chondrocytes Is Lost after Puberty
OBJECTIVE Telomere length and telomerase activity are important indicators of cellular senescence and replicative ability. Loss of telomerase is associated with ageing and the development of osteoarthritis. Implantation of telomerase-positive cells, chondrocytes, or stem cells expressing a normal chondrocyte phenotype is desired for cartilage repair procedures. The objective of this study was t...
متن کاملTelomerase activity is lost in articular chondrocytes after puberty
INTRODUCTION Increased age is the most significant predisposing factor for the development of osteoarthritis (OA). As age increases, cells reach replicative senescence, the maximum number of times a somatic cell can divide. It has been suggested in previous studies that replicative scenescence is initiated by telomere erosion, which occurs after the chromosomal telomere falls below a critical l...
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To obtain the large amount of T cells required for adoptive immunotherapy in a clinical setting, T-cell lifespan extension by human telomerase reverse transcriptase (hTERT) transduction is of particular interest. However, constitutive expression of hTERT is associated with malignant transformation and thus warrants a detailed evaluation of the safety of hTERT-transduced T cells before clinical ...
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The paper highlights risks that accompany losing a locked iOS device regarding confidentiality of passwords stored in the keychain. It presents results of handson tests that show the possibility for attackers to reveal some of the keychain entries. For the described approach, the knowledge of the user’s secret passcode is not needed, as the protection provided by the passcode is bypassed.
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Depression is in the news! In this country the Defeat Depression Campaign (Royal College of Psychiatrists, 1993) launched by the Royal Colleges of Psychiatrists and of General Practitioners is both consensus driven and media directed; to this may be added the emergence of consensus statements on depression treatment elsewhere in the world. Suicide reduction as a national health outcome target (...
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ژورنال
عنوان ژورنال: Chromosoma
سال: 2015
ISSN: 0009-5915,1432-0886
DOI: 10.1007/s00412-015-0528-7